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The CHEST Foundation’s research and distinguished scholar grants are geared toward higher-level translational research projects. According to the National Institutes of Health, translational research is defined as:

  1. The process of applying discoveries generated during research in the laboratory, and in preclinical studies, to the development of trials and studies in humans (as well as the process of applying bedside observations to inform bench to discoveries); and
  2. Research aimed at enhancing the adoption of best practices in the community. In more everyday terms you might think of translational research as moving the research process through phases from bench to animal to human to guidelines development to public health and ultimately to population outcomes and global health.

T-Level Definitions

Basic Biomedical Science or Discovery1

  • Goal is to understand the human condition and environment as it exists
  • Focuses on understanding biological, social and behavioral mechanisms that underlie health or disease, defining mechanisms, targets, or lead molecules1,6
  • Studies mechanisms or derive modifications of cells, proteins, and DNA that are present in human disease processes1
    • The condition of humans
      • Often a statement or declaration identifying a human status 
        • E.g. "fMRI in Adults with Alzheimer's" or "fMRI in Adults with Alzheimer's and Depression"
    • The environment in which humans exist

        • Often the identification, creation, engineering, or analysis of environmental elements

       

  • Does not include:
    • Interventions with human subjects or relationships that may alter the human condition or its environment
  • T0 Examples of the human condition
    • Bio-markers, cells, proteins, DNA, tissues, chemistries
    • Physical assessments radiology, laboratory, biopsy
    • Registries, surveys, data banks
    • Natural histories, observations, patterns, classifications, correlations
    • Gene mappings, banking, sequencing
  • T0 Examples of the human environment
    • “Bench science” or “Raw science”
    • Preclinical (Animal) models – “proof of Mechanism”
    • Chemicals, molecules, devices, structures
  • May or may not consider a particular disease process